Objective The objective of this study was to provide a way to assess the nutritional status of patients and to afford targeted nutritional supports during the radiotherapy on the basis of the laboratory parameters related to nutrition and chest muscle size in lung cancer patients at the different time.Methods The laboratory parameters were obtained in a cohort of 160 lung cancer patients who received thoracic radiotherapy in our department from March 2012 to November 2015.Fourteen patients who had complete chest CT scan images during radiotherapy were selected to evaluate chest muscles volume.The Chest muscles and its volume were delineated and calculated by CT scan images.Results The levels of(Hemoglobin)HGB,lymphocyte,total protein and albumin were decreased in different degrees during and after radiotherapy,which had the positive correlation with the number and doses of radiotherapy(P<0.05).The changes of hemoglobin and lymphocyte were more obviously among them;these indicators began to recover after 5 weeks of radiotherapy.Chest muscle volume was also the same as the trend of hematological indicators(P>0.05).Conclusion Cancer patients were prone to suffer from malnutrition during radiotherapy.The intake of energy and protein was less than the requirements.We should always take the nutritional status of patients into account and provide targeted nutritional support to improve treatment tolerance and quality of life of patients during radiotherapy.%目的 通过营养相关实验室检查与胸部肌肉的变化分析肺癌患者在放疗前、中、后的营养状况,指导临床对患者的营养状况及时评估并给予针对性营养支持.方法 选取于2012年3月-2015年11月到我科行胸部放疗的肺癌患者160例,对放疗不同时间相关实验室检查指标数据进行营养评估,并选取放疗前后有完整CT资料的14例患者,在CT图像的基础上对其胸部肌肉体积变化进行统计与分析.结果 放疗中及放疗结束后血红蛋白、淋巴细胞、总蛋白及白蛋白均有不同程度的下降(P<0.05),与放疗次数和剂量呈正相关,其中血红蛋白和淋巴细胞的变化更为明显,这些指标在放疗5周后才逐渐开始恢复;胸部肌肉体积也有相同的变化趋势(P>0.05).结论 放疗期间患者易出现营养不良.患者的能量和蛋白质摄入均低于机体需要量,应当关注肺癌患者在放疗过程的营养状况,做好及时评估、给予针对性营养支持工作,提高患者的治疗耐受和生活质量.
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