麻醉药物对围术期癌症患者免疫功能的影响

摘要

癌症引起的免疫抑制可加速癌细胞的扩散和转移,导致围术期癌症患者病情进一步恶化.手术作为治疗癌症的重要手段在临床中应用广泛,但手术引起的过度应激反应同样会引起免疫抑制.麻醉药物可抑制围术期内由手术创伤及疼痛导致的过度应激反应,但同时又直接或间接地影响着人体的免疫功能.本文将回顾不同麻醉药物与围术期癌症患者免疫功能之间的关系,为临床治疗提供依据.%Immune suppression caused by cancer can accelerate the spread and metastasis of cancer cells,resulting in further deterioration of perioperative cancer patients. Surgery is an important method of cancer treatment,which is widely used in clinical prac-tice. However,surgery-induced over-stress response can also cause immunosuppression. Anesthetics can inhibit excessive stress re-sponse caused by surgical trauma and pain in the perioperative period,but at the same time it directly or indirectly affects the body′s immune function. This article reviews the relationship between different anesthetic drugs and immune function in patients with periop-erative cancer,providing basic information for clinical treatment.