目的：探讨尼莫地平联合帕伐他汀预防蛛网膜下腔出血后脑血管痉挛的临床效果及对内皮素－1（ET-1）、一氧化氮（ NO）的影响。方法将82例蛛网膜下腔出血患者抽签随机分为观察组与对照组各41例，对照组采取尼莫地平治疗，观察组采取尼莫地平联合帕伐他汀治疗，比较两组蛛网膜下腔出血后不良事件发生率及ET-1、NO水平变化。结果观察组脑血管痉挛发生率低于对照组（P＜0.05）；观察组治疗后3、7、14 d时ET-1显著低于对照组（P＜0.05），NO显著高于对照组（P＜0.05）。结论尼莫地平联合帕伐他汀预防蛛网膜下腔出血后脑血管痉挛效果显著。%Objective To investigate the clinical effect of nimodipine combined with atorvastatin in the prevention of cerebral vasospasm after subarachnoid hemorrhage and analyze the effect of drug combination on ET-1 and NO.Methods Eighty-two patients with subarachnoid hemorrhage were randomly divided into the observation or the control group,41 in each group.The control group was treated with nimodipine while the observation group was treated with nimodipine combined with atorvastatin.The incidence rate of ad-verse events and changes of ET-1 and NO levels after subarachnoid hemorrhage were compared between the two groups.Results The incidence rate of cerebral vasospasm in the observation group was significantly lower than that in the control group( P<0.05) .After the 3d,7d and 14d of the treatment,ET-1 in the observation group were significantly lower than that in the control group(P<0.05)while NO in the observation group were significantly higher than that in the control group( P<0.05) .Conclusion The effect of nimodipine combined with atorvastatin in the prevention of cerebral vasospasm after subarachnoid hemorrhage is significant,which is considered to be related to reduce the ET-1 level and increase the NO level.
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