METHOD FOR CORRECTION OF ENDOTHELIAL DYSFUNCTION WITH COMBINATION OF ROSUVASTATIN AND THIOCTIC ACID IN HYPOOESTROGEN-L-NAME-INDUCED NICTIC OXIDE DEFICIENCY

摘要

FIELD: medicine.;SUBSTANCE: method involves simulating a dysfunction by performing a bilateral ovariectomy in Wistar male rats. On the 43rd postoperative days, L-nitro-arginine-methyl ester (L-NAME) is administered intragastrically in a dose of 25 mg/kg daily during 7 days. The induced dysfunction is corrected by daily intragastric administration of Rosuvastatin 0.85 mg/kg and thioctic acid 50 mg/kg during 7 days concurring with the administration of L-NAME into the rats.;EFFECT: method provides activating the correction of the endothelial dysfunction in hypooestrogenemia.;1 tbl, 1 ex