目的 观察三氧化二砷经导管肝动脉化疗栓塞介入治疗中晚期原发性肝癌的临床疗效和安全性.方法 选取2013年4月至2015年6月我院收治的中晚期原发性肝癌104例,分为观察组及对照组各52例,对照组患者采用常规的肝动脉栓塞治疗方法,观察组采用三氧化二砷联合经导管肝动脉化疗栓塞介入治疗方法.观察两组患者近期临床疗效,1、2年生存率和不良反应情况.结果 观察组与对照组的总有效率分别是65.38%(34/52)与48.04%(25/52),差异有统计学意义(P<0.05);中位生存时间分别是12.68个月与7.97个月;1、2年生存率分别是(81.28+4.93)%,(43.28+6.49)%和(57.48+4.21)%,(35.92+7.38)%,两组患者1年总生存率比较差异有统计学意义(P<0.05),而2年总生存率比较,差异无统计学意义(P>0.05).两组患者在治疗过程中均出现了谷草转氨酶与谷丙转氨酶的升高,白蛋白降低,胆红素异常以及心电图异常的不良反应,差异有统计学意义(P<0.05).结论 三氧化二砷经导管肝动脉化疗栓塞介入治疗中晚期原发性肝癌患者是一种安全有效的治疗方法,对临床有重要的参考价值.%Objective To observe the clinical efficacy and safety of arsenic trioxide ( As2 O3 ) via transcatheter arterial chemo-embolization (TACE) in the treatment of advanced primary liver cancer (HCC).Methods From April 2013 to June 2015,104 pa-tients with advanced primary HCC treated in our hospital were divided into observation group and control group ,52 in each group .The control group received therapy of hepatic artery embolization while the observation group received arsenic trioxide combined with tran -scatheter hepatic arterial chemoembolization interventional therapy .The short-term clinical efficacy ,1-year and 2-year survival rate and incidence of adverse reactions were observed in the both groups .Results The total effective rate of the observation group and the con-trol group was 65.38%(34/52) and 48.04%(25/52),respectively.The difference was statistically significant (P<0.05).The me-dian survival time of patients in observation group was 12.68 months and 7.97 months ,respectively .The 1-and 2-year survival rates in the observation group were (81.28±4.93)%and (43.28±6.49)%,respectively and (57.48±4.21)%and (35.92±7.38)%in the control group ,respectively .The 1-year survival rates between the two groups was significantly different ( P <0.05 ) but not the 2-year survival rate ( P>0.05 ) .The patients in the both groups appeared an increase of aspartate aminotransferase and alanine aminotrans -ferase,a decrease of albumin ,and abnormalities of bilirubin and ECG during the course of treatment when compared to before treatment ( P<0.05 ) .Conclusion Transcatheter arterial chemoembolization with arsenic trioxide is an effective and safe method for the treat -ment of patients with advanced primary liver cancer .It has a great reference value to clinical practice .
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