Objective To analyze the correlation between carotid intima media thickness ( CIMT ), ambulatory arterial stiffness index( AASI) and depression. Methods From 2012 to 2014 in the First People's Hospital of Zhaoqing,a total of 510 people undergoing routine physical examination were enrolled in this study,and they were divided into three groups according to BDI-Ⅱ:A group without depression(BDI-Ⅱ score<10,n=306),B group with mild depression(BDI-Ⅱscore 10-18,n =136),C group with moderate or severe depression(BDI -Ⅱ score≥19,n =68). General information ( including gender, age, BMI, incidence of hypertension and type 2 diabetes mellitus, smoking rate ), biochemical index (including TC,HDL-C,LDL-C,hs-CRP、IL-6),CIMT and AASI were compared among the three groupss,and their correlations with depression were analyzed. Results No statistically significant differences of gender, BMI, incidence of hypertension or type 2 diabetes mellitus,smoking rate,HDL-C was found among the three groups(P<0. 05);the proportion of female,LDL-C,hs-CRP,IL-6 and AASI of C group were statistically significantly higher than those of A group,while TC of C group was statistically significantly lower than that of A group,CIMT of C group was statistically significantly higher than that of A group and B group,respectively(P<0. 05). hs-CRP of B group was statistically significantly higher than that of A group( P<0. 05 ). CIMT and AASI of female were statistically significantly higher than those of male in groups B and C. Multivariate Logistic regression analysis showed that,female〔OR=2. 13,95%CI(1. 62,3. 95)〕,hs-CRP〔OR=1. 79, 95%CI(1. 56,2. 43)〕,IL-6〔OR=2. 46,95%CI(1. 59,3. 02)〕,CIMT〔OR=3. 78,95%CI(2. 01,4. 21)〕and AASI〔OR=2. 26,95%CI(1. 73,3. 14)〕were risk factors of depression(P<0. 05). Conclusion CIMT and AASI are risk factors of depression,and can be used as screening index for depression.%目的：探讨颈动脉内膜中层厚度（ CIMT）及动态动脉硬化指数（ AASI）与抑郁症的关系。方法选取2012—2014年在广东省肇庆市人民医院体检中心进行常规体检的510例体检者，均进行贝克抑郁量表（ BDI-Ⅱ）筛查，根据得分情况分为3组：<10分为无抑郁组（ n=306），10～18分为轻度抑郁组（ n=136），≥19分为中-重度抑郁组（n=68）。比较3组受试者一般资料〔性别、年龄、体质指数（BMI）、高血压发生率、吸烟率及2型糖尿病发生率〕、生化指标〔总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、超敏C反应蛋白（hs-CRP）、白介素6（IL-6）〕、CIMT及AASI，并分析其与抑郁症的关系。结果3组受试者年龄、BMI、高血压发生率、吸烟率、2型糖尿病发生率、HDL-C水平比较，差异无统计学意义（ P>0.05）；中-重度抑郁组女性患者比例大于无抑郁组，TC水平低于无抑郁组，LDL-C、hs-CRP、IL-6水平及AASI均高于无抑郁组，CIMT大于无抑郁组及轻度抑郁组（P<0.05）。轻度抑郁组患者hs-CRP水平高于无抑郁组（P<0.05）。轻度抑郁组及中-重度抑郁组女性患者 CIMT 大于男性， AASI 高于男性（ P <0.05）。多因素 Logistic 回归分析结果显示，女性〔OR =2.13，95%CI（1.62，3.95）〕、hs-CRP〔OR =1.79，95%CI（1.56，2.43）〕、IL-6〔OR =2.46，95%CI（1.59，3.02）〕、CIMT〔OR=3.78，95%CI（2.01，4.21）〕和AASI〔OR=2.26，95%CI（1.73，3.14）〕是抑郁症的危险因素（P<0.05）。结论 CIMT和AASI是抑郁症的危险因素，临床筛查抑郁症时可参考该指标。
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