Global tuberculosis epidemic situation began to rise due to mycobacterium tuberculosis resistance since the 1990s,China is one of thirty high tuberculosis burden countries in the world.In recent years,drug - resistant tuberculosis significantly increased due to delayed diagnosis,improper chemotherapy,poor management and so on,treatment of drug -resistant tuberculosis is more difficult which need combination of second -line antituberculosis drugs,but now second -line antituberculosis drugs have high risk of toxic and side effects and poor overall control effect,mostly are expensive.As the advances in molecular biology,diagnostic techniques for tuberculosis especially for drug - resistant tuberculosis rapidly advanced.This paper reviewed the progress on laboratory diagnostic methods for drug-resistant tuberculosis,in order to provide a reference for the clinical diagnosis and treatment.%20世纪90年代以来全球结核病疫情开始回升,而结核分枝杆菌耐药是导致结核病发病率升高的重要原因之一,我国是全球30个结核病高负担国家之一.近年来,由于诊断延迟、化疗不当或管理不善等而导致耐药结核病增多,治疗难度增加,常需联合二线抗结核药物,但目前临床上所用二线抗结核药物不仅毒副作用较大、费用较昂贵,且整体控制效果较差.近年来,随着分子生物学技术发展,结核病诊断技术尤其是耐药结核病诊断技术突飞猛进.本文主要综述了耐药结核病实验室诊断方法的研究进展,旨在为耐药结核病的诊治提供参考.
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