血浆氨基末端脑钠肽前体水平与慢性阻塞性肺疾病急性加重期患者心肺功能及生活质量的关系研究

摘要

Objective To analyze the relationship between plasma NT-proBNP level and cardiopulmonary function,and quality of life in patients with AECOPD.Methods From January 2013 to April 2017,a total of 60 patients with AECOPD were selected in the Traditional Chinese Medicine Hospital of Xiangcheng District,Suzhou,and they were divided into normal group(n=35)and elevation group(n=25)according to plasma NT-proBNP level.Index of cardiac function and pulmonary function,and quality of life were compared between the two groups,correlation between plasma NT-proBNP level and index of cardiopulmonary function in patients with AECOPD was analyzed by Pearson correlation analysis.Results LAD,RAD,LVESD and LVEDD of elevation group were statistically significantly larger than those of normal group,while LVEF of elevation group was statistically significantly lower than that of normal group(P<0.05).FVC and FEV1 of elevation group were statistically significantly smaller than those of normal group,FEV1/FVC of elevation group was statistically significantly lower than that of normal group,MMEF and PEF of elevation group were statistically significantly slower than those of normal group(P<0.05).Physical function score,physical role score,limb pain score,general health score,vitality score,social function score,emotional role score and mental health score of elevation group were statistically significantly lower than those of normal group(P<0.05).Pearson correlation analysis results showed that,plasma NT-proBNP level was negatively correlated with LVEF(r=-0.379),FVC(r=-0.295),FEV1(r=-0.351),FEV1/FVC(r=-0.365),MMEF(r=-0.521)and PEF(r=-0.437),respectively,was positively correlated with LAD(r=0.349),RAD(r=0.421),LVESD(r=0.459)and LVEDD(r=0.521),respectively(P<0.05).Conclusion Plasma NT-proBNP level is significantly correlated with the cardiopulmonary function of patients with AECOPD,and the quality of AECOPD patients with elevated plasma NT-proBNP level is relative poor.%目的 分析血浆氨基末端脑钠肽前体(NT-proBNP)水平与慢性阻塞性肺疾病急性加重期(AECOPD)患者心肺功能及生活质量的关系.方法 选取2013年1月-2017年4月苏州市相城区中医医院呼吸内科收治的AECOPD患者60例,根据血浆NT-proBNP水平分为NT-proBNP正常者35例(正常组)和NT-proBNP升高者25例(升高组).比较两组患者心功能指标、肺功能指标及生活质量,血浆NT-proBNP水平与AECOPD患者心肺功能指标的相关性分析采用Pearson相关性分析.结果 升高组患者左心房内径(LAD)、右心房内径(RAD)、左心室收缩末期内径(LVESD)及左心室舒张末期内径(LVEDD)大于正常组,左心室射血分数(LVEF)低于正常组(P<0.05).升高组患者用力肺活量(FVC)和第1秒用力呼气容积(FEV1)小于正常组,第1秒用力呼气容积与用力肺活量比值(FEV1/FVC)低于正常组,最大呼气中段流速(MMEF)和呼气峰值流速(PEF)慢于正常组(P<0.05).升高组患者躯体功能、躯体角色、肢体疼痛、总体健康、活力、社会功能、情绪角色及精神健康评分低于正常组(P<0.05).Pearson相关性分析结果显示,血浆NT-proBNP水平与AECOPD患者LVEF(r=-0.379)、FVC(r=-0.295)、FEV1(r=-0.351)、FEV1/FVC(r=-0.365)、MMEF(r=-0.521)、PEF(r=-0.437)呈负相关,与LAD(r=0.349)、RAD(r=0.421)、LVESD(r=0.459)、LVEDD(r=0.521)呈正相关(P<0.05).结论 血浆NT-proBNP水平与AECOPD患者心肺功能有关,且血浆NT-proBNP水平升高患者生活质量较差.