甘露醇与吡拉西坦注射液治疗颅内肿瘤术后高颅内压的疗效观察

摘要

Objective To study the efficacy and safety of mannitol and piracetam injection for postoperative high in -tracranial pressure in intracranial tumor .Methods 76 cases of intracranial tumor patients with high intracranial pressure in ac-cordance with admission time were divided into the control group and the observation group ,each with 38 cases.The control group received 20%mannitol infusion,and the observation group were treated with 20% piracetam injection.Clinical efficacy,adverse reactions ,and the signs and symptoms of increased intracranial pressure before and after treatment of the 2 groups were recorded . Results The onset time,peak time,duration,intracranial pressure reduction of the observation group were respectively (0.47 ± 0.21) h,(1 ±0.42) h,(4.31 ±1.41) h,(10.81 ±4.41) mmHg,and those of the control group were (0.48 ±0.23) h,(0.98 ±0.45) h,(4.35 ±1.37) h,(10.69 ±4.47) mmHg (P>0.05).The effective rates of the observation group and the control group were 94.74%(36/38) and 92.11%(35/38) (P>0.05);there had no obvious adverse reactions in both groups ,and blood test ,electrolytes and liver and kidney function before and after treatment had no abnormality .Conclusion Compared with mannitol,piracetam injection for postoperative high intracranial pressure in intracranial tumor has similar curative effect ,and ei-ther treatments has no obvious adverse reactions .The onset time and other indicators of the 2 treatments has no significant differ-ence,so the clinical treatment of postoperative high intracranial pressure in intracranial tumor patients should be decided accord -ing to the actual situation of patients .%目的：探讨甘露醇与吡拉西坦注射液治疗颅内肿瘤术后高颅内压的疗效及安全性。方法将76例颅内肿瘤术后高颅内压患者按照住院时间先后顺序分为对照组与观察组，各38例。对照组采用20％甘露醇快速静脉滴注，观察组采用20％吡拉西坦注射液治疗。统计2组患者临床治疗效果和不良反应及用药前、后颅内压增高体征及症状等情况。结果观察组用药起效时间、高峰时间、持续时间、降压幅度分别为（0．47±0．21） h、（1．00±0．42） h、（4．31±1．41）h、（10．81±4．41）mmHg，与对照组（0．48±0．23）h、（0．98±0．45）h、（4．35±1．37）h、（10．69±4．47）mmHg比较，P＞0．05。观察组治疗有效率为94．74％（36／38），与对照组92．11％（35／38）比较，P＞0．05；2组患者均未发生明显性不良反应，且治疗前后血常规和电解质及肝肾功能均无异常。结论相比甘露醇来说，颅内肿瘤术后高颅内压患者采用吡拉西坦注射液治疗效果相当，且二者均无明显不良反应，起效时间等指标均无明显差异性，因此临床治疗颅内肿瘤术后高颅内压患者可根据患者实际情况选择吡拉西坦注射液与甘露醇治疗。