奥沙利铂联合表柔比星经肝动脉化疗栓塞术治疗原发性肝癌的临床观察

摘要

目的 探讨奥沙利铂联合表柔比星经肝动脉化疗栓塞术(TACE)治疗原发性肝癌的疗效.方法 将原发性肝癌患者80例随机分为对照组和观察组,均40例.对照组应用单纯肝动脉栓塞治疗,观察组给予奥沙利铂联合表柔比星经TACE治疗.比较2组血清中癌胚抗原(CEA)和甲胎蛋白(AFP)水平、不良反应、疗效及治疗后1年内死亡率.结果 治疗后6周,观察组患者血清中CEA和AFP水平显著低于对照组(P<0.01).观察组患者的总缓解率为62.50%,显著高于对照组为37.50%(P<0.05).观察组患者的恶心呕吐发生率明显高于对照组(P<0.05),2组发热等其他不良反应发生率差异无统计学意义(P>0.05).对照组1年内有10例死亡(25.00%),观察组死亡2例(5.00%),2组差异有统计学意义(χ2=4.793,P<0.05).结论 奥沙利铂联合表柔比星经肝动脉化疗栓塞术治疗原发性肝癌疗效确切,且安全性好.%Objective To observe the efficacy of TACE with infusion of oxaliplatin combined with pirarubicin in treating primary liver cancer. Methods 80 cases with primary liver cancer were randomly divided into the control group and the observa-tion group. Control group was treated by simple transarterial embolization. The observation group was given with TACE with infu-sion of oxaliplatin combined with pirarubicin. Serum levels of AFP and CEA,untoward effect,efficacy,and death rate within 1 year were compared in the 2 groups. Results Serum levels of CEA and AFP of the observation group were obviously lower than the control group(P<0. 01). Total survival rate of the observation group was 62. 50%,which was superior to the control group, 37. 50%(P<0. 05). Incidence rate of nausea and vomitting of the observation group was obviously higher than the control group (P<0. 05). There was no statistical significance in incidence rate of fever and so on untoward effect in both groups(P>0. 05). Within 1 year,10 cases(25. 00%) were dead in the control group,which was evidently higher than the observation group,2 cases (5. 00%) (χ2 =4. 793,P<0. 05). Conclusion Efficacy of TACE with infusion of oxaliplatin combined with pirarubicin for primary liver cancer is significant and safe.