目的 探讨长效醋酸甲羟孕酮对子宫内膜癌组织中血管内皮生长因子的影响.方法 选择原发性子宫内膜癌患者80例作为观察组,同时选取80例正常增生期子宫内膜组织做对照.比较观察组治疗前后与对照组VEGF的表达情况.结果 治疗前,观察组中VEGF阳性表达较对照组高,差异具有统计学意义(χ2=46.673,P<0.05);治疗后,2组VEGF阳性表达率比较,差异具有统计学意义(χ2=6.972,P<0.05).治疗后,观察组VEGF阳性表达较治疗前降低,差异具有统计学意义(χ2=14.171,P<0.05).治疗前和治疗后,子宫内膜癌患者病变组织中VEGF表达在不同年龄、组织分级、病理分期、病理类型、肌层浸润深度有不同,差异具有统计学意义(P均<0.05).结论 VEGF可通过促进血管形成参与到子宫内膜癌的发生发展过程,采用长效醋酸甲羟孕酮治疗子宫内膜癌可降低患者血管内皮生长因子的表达,从而抑制肿瘤的发生发展.%Objective To investigate the effect of long-acting medroxyprogesterone acetate on the expression of vascular endothelial growth factor in endometrial cancer .Methods 80 pregnancies with endometrial cancer were selected as the observa-tion group and 80 healthy women were selected as the control group .Compared the expression of vascular endothelial growth factor before and after treatment .Results Before treatment ,the difference of total effective rate for VEGF between both groups was sta-tistically significant(χ2 =46.673,P<0.05),the total effective rate for VEGF of the control group was lower than the observation group.After treatment , the difference of total effective rate for VEGF between both groups was statistically significant (χ2 =6.972,P<0.05).The difference of total effective rate for VEGF of the observation group before and after treatment was statisti -cally significant (χ2 =14.171,P<0.05),the total effective rate for VEGF after treatment was lower than before treatment .The total effective rate of VEGF was different for different ages ,Tissue grading ,pathological stage ,pathological type ,depth of muscular invasion before and after treatment (P<0.05).Conclusion The vascular endothelial growth factor may participate in the occur-rence and development of endometrial cancer by promoting angiogenesis .It can reduce the expression of vascular endothelial growth factor in serum of endometrial cancer treated by long-acting medroxyprogesterone acetate to inhibit the occurrence and de-velopment of tumor .
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