慢性肾功能衰竭患者在血液透析期间恶性肿瘤的发病状况及其发病原因

摘要

Objective To investigate the incidence of malignant condition and risk factors of chronic renal failure pa -tients during hemodialysis .Methods 69 patients diagnosed with chronic renal failure were selected for the study ,including 34 patients with azotemia ,35 patients with uremia ,a retrospective analysis of patients enrolled the incidence of malignant tumors ,and analyze the situation of the primary disease ,cancer related risk factors were analyzed for chronic renal failure during hemodialysis method using chi-square test and regression analysis .Results The incidence of malignancy in patients with chronic renal failure was higher than the patients with azotemia ,the difference was statistically significant (P<0.05).The incidence of urological tumors was highest in patients with malignant tumors ,followed by digestive system tumors .The mean age of malignancy in patients with chronic renal failure was higher than that in non-tumor patients,and the rate of glomerular filtration was lower than that of non-tumor patients (P<0.05).The incidence of primary disease in patients with aristolochic acid nephropathy was the highest , and the difference was statistically significant (P<0.05).Aging,glomerular filtration rate reduction is chronic renal failure ure-mic malignant tumor risk factors .Conclusion Incidence of malignant condition of chronic renal failure patients during hemodial -ysis is higher than patients with uremia azotemia;advanced age ,decreased glomerular filtration are important factors leading to ma-lignant tumors ,of which the highest proportion is urologic tumor .%目的 探讨慢性肾功能衰竭患者在血液透析期间恶性肿瘤的发病状况及其发病相关危险因素.方法纳入慢性肾功能衰竭患者69例作为研究对象,其中氮质血症期患者有34例,尿毒症患者35例,回顾性分析入选患者的恶性肿瘤发生率,并分析原发病的情况,采用卡方检验和回归分析的方法对慢性肾功能衰竭血液透析期间恶性肿瘤发生的相关危险因素进行分析.结果慢性肾功能衰竭尿毒症期患者恶性肿瘤的发病率高于氮质血症期患者,差异具有统计学意义(P<0.05).在发生恶性肿瘤的患者中泌尿系肿瘤的发生率最高,其次为消化系统肿瘤.慢性肾功能衰竭尿毒症期患者发生恶性肿瘤患者的平均年龄要高于未发生肿瘤患者,肾小球滤过率低于未发生肿瘤患者,差异具有统计学意义(P<0.05).原发病马兜铃酸肾病患者的肿瘤发病率最高,不同原发病肿瘤发病率之间差异具有统计学差异(P<0.05).高龄、肾小球滤过率降低是慢性肾功能衰竭尿毒症期恶性肿瘤发生的危险因素.结论慢性肾功能衰竭尿毒症期恶性肿瘤的发病率高于氮质血症期患者,高龄、肾小球滤过率下降是导致恶性肿瘤发病的重要因素,其中以泌尿系肿瘤所占比例最高.