Objective To investigate the serum levels of E-cadherin and Galectin-9 in colon cancer and clinical significance.Methods 88 patients with colon cancer were selected.50 patients of healthy people were the control group.Levels of Ecadherin and Galectin-9 in serum samples were detected in both groups was analyzed.Results Levels of E-cadherin and Galectin-9 in colon cancer group were obviously lower than those of the control group(P ＜ 0.05).Levels of E-cadherin and Galectin-9 were not related to age,gender,tumor diameter,and tumor site in colon cancer patients (P ＞ 0.05),and were evidently related to stage and carcinoma cell differentiation (P ＜ 0.05).Levels of E-cadherin and Galectin-9 in death group were remarkably lower than survival group (P ＜ 0.05).Conclusion Levels of E-cadherin and Galectin-9 of colon cancer patients in serum are obviously decreased,are related with stage and carcinoma cell differentiation,and the effective indicators of clinical prognosis.%目的 分析与检测结肠癌患者血清中E-钙粘蛋白和半乳糖凝集素-9水平以及临床意义.方法 选择结肠癌患者88例,健康体检者50例作为对照观察.采用酶联免疫吸附法检测两组血清E-钙粘蛋白和半乳糖凝集素-9水平.结果 与对照组相比,结肠癌组血清E-钙粘蛋白和半乳糖凝集素-9水平显著降低(P＜0.05).血清E-钙粘蛋白和半乳糖凝集素-9水平与结肠癌患者年龄、性别、瘤灶直径、癌灶部位无明显相关性(P＞0.05),与临床分期和肿瘤分化程度显著相关(P＜0.05).死亡组患者E-钙粘蛋白和半乳糖凝集素-9水平显著低于存活组(P＜0.01).结论 结肠癌患者血清中E-钙粘蛋白和半乳糖凝集素-9水平明显降低,与结肠癌的恶性程度相关,对该病的临床预后评价具有重要价值.
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