异甘草酸镁对改善肝癌射频消融术后肝损伤的临床价值

摘要

Objective To study the clinical value of magnesium isoglycyrrhizinate in improving liver injury of liver canc -er after radiofrequency ablation.Methods 98 cases of primary liver cancer were collected,all patients underwent radiofrequency ablation,were randomly divided into the experimental group treated with postoperative magnesium isoglycyrrhizinate treatment,and the control group(treated with postoperative diammonium glycyrrhizinate treatment),each with 49 cases.The changes of liver function before and after treatment in the 2 groups were compared and analyzed.Results Before treatment and 1 d after treat-ment,AST,ALT levels of the 2 groups were not statistically different(P>0.05);after the treatment of 7 d the level of AST and ALT in the experimental group was significantly better than the control group,with statistically significant difference between the 2 groups(P<0.05).The level of TBIL between the 2 groups before and 1d after treatment was not statistically significant(P>0.05),the level of TBIL in patients with 7 d was significantly lower than that of the control group,and the difference was statisti-cally significant(P<0.05).Before treatment,the 2 groups of patients with liver cell synthesis and reserve the difference had no statistically difference(P>0.05);1 d and 7 d after the treatment,the experimental group and the control group were significant-ly improved compared with before treatment,the difference was statistically significant(P<0.05);the difference between the 2 groups was not statistically significant(P>0.05).7 d after treatment,the effective rate of the experiment group was 38.8%,inef-ficiency rate was 2.0%,total effective rate was 89.8%,which were significantly better than the control group,the difference was statistically significant(P<0.05).Conclusion Magnesium isoglycyrrhizinate is effective in improving liver function after radio-frequency ablation of liver cancer,and the total effective rate is high,and the clinical value is positive.%目的 研究异甘草酸镁对改善肝癌射频消融术后肝损伤的临床价值.方法 收集接受肝癌射频消融术的原发性肝癌患者98例,随机分为实验组(术后异甘草酸镁治疗)49例,对照组(术后甘草酸二胺治疗)49例,对比分析2组患者治疗前后肝功能改变情况.结果 治疗前以及治疗后1 d,2组患者AST、ALT水平差异不具统计学意义(P>0.05);治疗后7 d实验组AST和ALT水平显著优于对照组,组间差异具统计学意义(P<0.05).2组患者治疗前和治疗后1 d TBIL水平变化差异不具统计学意义(P>0.05);治疗后7 d实验组患者TBIL水平明显低于对照组,差异具统计学意义(P<0.05).治疗前,2组患者肝细胞合成储备功能差异不具统计学差异(P>0.05);治疗后1 d和7 d 实验组和对照组患者均较治疗前有明显改善,差异具统计学意义(P<0.05);组间差异不具统计学意义(P>0.05).治疗后7 d实验组显效率38.8%、无效率2.0%,总有效率89.8%,显著优于对照组,差异具统计学意义(P<0.05).结论 异甘草酸镁对改善肝癌射频消融术后肝功能具有改善作用,治疗总有效率高,临床价值肯定.