米非司酮对子宫肌瘤组织中ER、PR及EGFR的影响及其临床机制

摘要

Objective To observe the effect of mifepristone on the expression of ER,PR and EGFR in patients with uter-ine leiomyoma.Methods 60 patients with uterine leiomyoma were randomly divided into the control group(n=30)and the ob-servation group(n=30).The patients in the control group were treated with placebo before operation.The patients in the obser-vation group were treated with mifepristone before operation for 90 days.On the third day,the patients were treated with surgery. The levels of ER,PR and EGFR in the resected tissues were detected by immunohistochemistry.Group and the effects of ER,PR and EGFR levels.Results The levels of ER,PR and EGFR were not significantly different between the 2 groups before treatment (P>0.05).The levels of ER and PR in the observation group were significantly lower than those of the control group(P<0.05).There was no significant difference in the safety between the 2 groups(P>0.05).Conclusion Preoperative mifepristone for uterine leiomyoma is effective,can reduce the body's ER,PR and EGFR levels,it is worthy of application.%目的 探讨米非司酮对子宫肌瘤组织中ER、PR及EGFR的影响.方法 取子宫肌瘤患者60例,随机分为对照组(n=30)和观察组(n=30).对照组术前采用安慰剂治疗;观察组术前采用米非司酮治疗,连续治疗90 d,停药第3天行手术治疗.采用免疫组化法测定切除组织的ER、PR及EGFR水平,比较2组临床疗效及对ER、PR及EGFR水平的影响.结果 观察组治疗后子宫体积、肌瘤体积小于对照组(P<0.05).2组治疗前ER、PR及EGFR水平差异无统计学意义(P>0.05);治疗后观察组ER、PR及EGFR水平,低于对照组(P<0.05).2组药物安全性比较,差异无统计学意义(P>0.05).结论 子宫肌瘤患者术前采用米非司酮治疗效果理想,能降低机体内ER、PR及EGFR水平,值得推广应用.