目的：探讨老年人血清氧化型低密度脂蛋白（ oxLDL）水平与颈动脉内膜中层厚度（ CA⁃IMT）的相关性，判断血清oxLDL水平升高与老年人颈动脉内膜中层增厚的关系。方法吴江区第一人民医院2013年10月至2014年2月行颈部动脉血管超声检查的住院老年患者217例，根据颈动脉彩色多普勒超声测量结果分为正常组113例，CA⁃IMT增厚组104例，同时记录患者一般临床资料并检测血脂和oxLDL水平，进行危险因素和相关性分析。结果老年人CA⁃IMT增厚组血清oxLDL水平显著高于正常组（ P＜0�01），多因素Logistic回归结果显示血清oxLDL回归系数最高（ OR＝2�911，P＜0�01），相关性分析显示血清oxLDL水平与CA⁃IMT显著相关（ r＝0�762， P＜0�01）。结论老年人血清oxLDL水平是CA⁃IMT增厚的较强危险因素，与CA⁃IMT厚度有着较高的相关性，具有一定的临床提示价值。%Objective To discuss whether the serum level of ox⁃LDL was associated with carotid artery intima media thickness ( CA⁃IMT) and further to study the role of serum ox⁃LDL in carotid artery stenosis. Methods 217 elderly inpa⁃tients of Wujiang First People�s Hospital during the period from Oct. 2013 to Feb. 2014 receiving the detection of carotid ar⁃tery color doppler ultrasound were enrolled.113 cases with CA⁃IMT<1�5 mm were divided into the normal group and 104 cases with CA⁃IMT ranging 0�9⁃1�5 mm were divided into the thickening group. The clinical data were recorded, and the level of blood lipid and serum ox⁃LDL of the patients were compared between the two groups and Logistic regression and correlation analysis were carried out. Results Serum levels of ox⁃LDL in the thickening group was significantly higher than that in the normal group(1�04±0�37 vs 0�86±0�47 mmol/L,P<0�01). The multiple Logistic regression indicated that serum ox⁃LDL level was the most important factor to CA⁃IMT ( OR=2�911,P<0�01) . The serum level of ox⁃LDL was sig⁃nificantly correlated with CA⁃IMT ( r=0�762, P<0�01) . Conclusions Serum level of ox⁃LDL of the elderly plays an important role in the prediction and diagnosis of CA⁃IMT.
展开▼
