Objective To explore clinical features, cerebrospinal fluid cytology and imaging findings in meningeal carcinomatosis. Methods The data of clinic, cerebrospinal fluid cytology and imaging findings of 12 patients with meningeal carcinomatosis were analyzed retrospectively, and relevant literatures were also reviewed. Results Headache, vomiting were the most of the capital symptoms of these meningeal carcinomatosis, cranial and spinal nerve damage and signs of meningeal irritation might be associated. There were abnormal levels of intracranial pressure in different extent, and tumor cells were found in the cytological examination of cerebrospinal fluid, while in the MRI enhanced scanning, abnormal linear and strip enhancement of meninges were noted. Conclusion Meningeal carcinomatosis are of some clinical manifestations, and both cerebrospinal fluid cytology results noting tumor cells and MRI enhanced scanning examination are important evidences in diagnosing meningeal carcinomatosis.%目的 探讨脑膜癌病的临床、脑脊液细胞学和影像学特点.方法 对12例诊断为脑膜癌病患者的临床资料进行回顾性总结,并结合文献进行分析.结果 临床首发症状以头痛、呕吐为主,可伴脑神经和脊神经损害及脑膜刺激征;脑脊液压力均不同程度增高,脑脊液中均找到癌细胞;头颅MRI增强扫描可见脑膜强化.结论 脑膜癌病临床表现有一定特征,脑脊液细胞学检查发现癌细胞,头颅MRI增强扫描发现脑膜强化对脑膜癌病的确诊有重要意义.
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