Objective To investigate the synergistic toxicity of hyperthermia combined with cisplatin on human ovarian cancer cells and the efficacy of the treatment on malignant ascites in ovarian cancer patients. Method 79 cases of ovarian cancer patients were randomized into either control group (n=39) or experimental group (n=40) ac-cording to random number table. The control group was given conventional cisplatin-based therapy, and cisplatin plus hyperthermia was administered in the experimental group. The efficacy, apoptosis of SKOV3 cells in 48h after treat-ment, the level of immune function related factors before and after treatment, quality of life (QoL) and adverse reac-tions of both groups were compared. Result 1) The clinical overall response rate (ORR) was 58.97% in control group, which was significantly lower than that in the experimental group (77.50%) (P <0.05); 2) The SKOV3 apopto-sis rate in 48 h after treatment was 72.5% in the experimental group, and was significantly higher than the 46.15% of the control group (P <0.05); 3) The CD4 and CD4 / CD8 levels after treatment were significantly higher than those before treatment in the experimental group and those after treatment in the control group (P<0.05), while those mea-sures maintained stable after treatment in the control group (P>0.05); 4) According to SF-12 QoL scale results, the relevant dimensions of QoL (general health, emotional function, bodily pain and mental health) scores were signifi-cantly higher in the experimental group compared with the control group (P<0.05); 5) The incidence of adverse reac-tions was 38.46% in the control group, and was 35.00% in the experimental group, with no significant differences ob-served (P>0.05). Conclusion Hyperthermia combined with cisplatin is of significant synergistic toxicity on human ovarian cancer cells and is effective in the treatment of malignant ascites in ovarian cancer.%目的：探讨热疗联合顺铂对人卵巢癌细胞的毒性增效作用及治疗卵巢癌恶性腹腔积液的疗效。方法将79例卵巢癌伴恶性腹腔积液患者按照随机数字表法随机分为对照组（n=39）与观察组（n=40），对照组仅采用顺铂进行常规治疗，观察组在此基础上联合热疗进行治疗。比较两组疗效、治疗48 h后SKOV3细胞凋亡情况、治疗前后免疫功能相关指标水平、生活质量及不良反应发生情况。结果①对照组临床总缓解率为58.97%，低于观察组的77.50%，差异有统计学意义（P＜0.05）；②观察组治疗48 h后SKOV3细胞凋亡率为72.5%，高于对照组的46.15%，差异有统计学意义（P＜0.05）；③观察组治疗后CD4及CD4/CD8水平均高于治疗前及对照组治疗后，差异有统计学意义（P＜0.05），对照组治疗前后各免疫功能指标水平比较，差异均无统计学意义（P＞0.05）；④根据SF-12生活量表评分，观察组患者生活量表相关维度（总体健康、情感职能、躯体疼痛及精神健康）评分均高于对照组，差异有统计学意义（P＜0.05）；⑤对照组不良反应发生率为38.46%，观察组为35.00%，差异无统计学意义（P＞0.05）。结论热疗联合顺铂对人卵巢癌细胞的毒性增效作用及治疗卵巢癌恶性腹腔积液的疗效显著。
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