目的:探讨胃癌患者血清白细胞介素及组织中转化生长因子-α水平的监测及其生物学行为.方法:用免疫组织化学方法检测胃癌患者转化生长因子-α蛋白的表达,用ELISA法检测胃癌患者血清白细胞介素-2、白细胞介素-6、白细胞介素-8、白细胞介素-18的蛋白浓度结果:胃癌患者的血清白细胞介素-6、白细胞介素-8、白细胞介素-18及组织中转化生长因子-α水平均高于健康人,血清白细胞介素-2水平低于健康人,差异有统计学意义(P＜0.05).结论:血清白细胞介素-2、白细胞介素-6、白细胞介索-8、白细胞介素-18及组织中转化生长因子-α共同参与了胃癌的发生、发展,与胃癌的生物学行为有关.%Objective: To monitor and biological behavior of transforming growth factor - α levels in gastric cancer patients serum and tissues. Methods: The expression of transforming growth factor - a protein detection in patients with gastric cancer by immunohistochemical method, ELBA was used to detect the serum of patients with gastric cancer interieukin -2, interieukin -6, interieukin -8, interieukin - 18 protein concentration. Results: The patients with gastric cancer serum interieukin - 6, interieukin - 8, interieukin -18 and transforming growth factor - α levels were higher than those in healthy people, the serum levels of interieukin -2 levels were significantly lower than that of the healthy people, the difference was statistically significant ( P < 0.05 ). Conclusion: The serum levels of interieukin - 2, interieukin - 6, interieukin - 8, interieukin -18 and transforming growth factor alpha in gastric carcino-genesis, development, related to the biological behavior of gastric carcinoma.
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