重度阻塞性睡眠呼吸暂停低通气综合征患者记忆与执行功能表现因素分析与对策

摘要

目的:分析影响重度阻塞性睡眠呼吸暂停低通气综合征(OSASH)患者记忆与执行功能的相关因素及对策.方法:选取40例重度OS-ASH患者为研究对象,并另选同一期间检查的40例体检健康志愿者为对照组.两组受试者均进行神经认知功能评估测试、记忆功能以及执行功能评估,并监测两组受试者睡眠呼吸指标.对比两组受试者所有测试指标数据,分析记忆功能与睡眠呼吸指标的关系.结果:研究组患者蒙特利尔认知功能评定量表(MoCA)、常识、图形回忆、视觉再现、逻辑记忆、数字广度评分均显著优于对照组,差异有统计学意义(P<0.05);研究组患者总应答数、完成分类数、正确应答数、错误应答数、持续性错误数、非持续性错误、画钟实验(CDT)评分均显著优于对照组,有统计学意义(P<0.05);研究组患者呼吸暂停低通气指数(AHI)、氧减指数(ODI)、最低SaO2、平均SaO2、TSat90、REM数据均显著优于对照组,差异有统计学意义(P<0.05).OSASH患者的认知功能各项指标与平均SaO2之间均呈正相关,与TSat90之间均呈负相关.结论:重度阻塞性睡眠呼吸暂停低通气综合征患者的记忆功能与执行功能受到严重损伤,且记忆功能损伤与睡眠呼吸障碍有关.%Objective:To analyze the factors affecting memory and executive function in Patients with severe obstructive sleep apnea hypopnea syndrome ( OSASH) and develop countermeasures. Methods:To select 40 patients with severe OSASH as the study subjects, and 40 healthy volunteers who were ex-amined during the same period were selected as the control group. Both groups performed neurocognitive assessment tests, memory functions, and executive function assessments, and monitored sleep respiratory index. The index data of all tests were compared to analyze the relationship between memory function and sleep respiratory index. Results:To compare Montreal cognitive function rating scale ( MoCA) , common sense, pattern recall, visually recapturing, logical memory, and digital breadth score, the research group were significantly better than the control group, the difference was statistically significant( P<0. 05);to compare the patiens' total number of responses, number of completed classifications, number of correct responses, number of false responses, number of durative errors, non-durative error, and the clock drawing test ( CDT) score, the research group was significantly better than the control group, with statistical significance(P<0. 05). To compare the data of apnea hypopnea index(AHI), oxygen desaturation index (ODI), the lowest SaO2, the mean SaO2, TSat90、REM, the research group was significantly better than the control group, and the difference was statistically significant(P<0. 05). The cognitive function of the OSASH patient was positively correlated with the average SaO2 and was negatively correlated with TSat90. Conclusion: The memory function and executive function of patients with severe obstructive sleep apnea-hypopnea syndrome were severely impaired, and memory impair-ment was associated with sleep-disordered breathing.