18F-FDG的制备及在小鼠体内分布研究

摘要

2-Deoxy-2-18F-fluoro-D-glucose (18F-FDG) was synthesized via nuclear reaction 18O(p，n)18F and nucleophilic substitution reaction by PET trace Cyclotron-FDG Synthesis System. The corrected radiochemical yield was about 54% and the radiochemical purity was above 95% by HPLC and TLC. The distribution of 18F-FDG in mice showed that the higher uptake rates of 18F-FDG in heart and brain were found， the radioactivity reteined in heart and brain for longer time and the radioactivity in kidney was rapidly cleared. The radioactivity in blood and organs dropped very slowly 30min after injection of 18F-FDG. The synthetic 18F-FDG allowed for PET study and diagnosis of patients.%采用PET trace回旋加速器-FDG合成系统,通过18O(p，n)18F核反应和亲核取代反应制备18F-FDG,放化产率约为54%,放化纯度大于95%。小鼠体内分布实验表明,18F-FDG 在心肌和脑中有较高的摄取率,且放射性持续时间较长,并通过肾脏迅速排出。注入18F-FDG 30 min后,放射性在血和各脏器中的分布逐渐达到平衡。制备的18F-FDG适于临床PET研究和诊断。