霞水母糖蛋白抗疲劳作用的实验研究

摘要

In order to investigate the effect of a kind of novel glycoprotein from Cyanea nozakii on the anti-fatigue activities of mice,glycoprotein aqueous solution were administered orally to the mice for 30 d with the dosage of 50,100,and 200 mg/kg. The loading forced swim time,serum urea nitrogen,glycogen content in liver,and blood lactate value were tested. The results showed that all of the dosage levels can prolong the swim time of mice (P < 0.01) , reduce the quantity of blood urea nitrogen(P<0.05 or P < 0.01) and decrease the content of the lactic acid in blood of mice evidently (P <0.01). Middle and high dose levels can increase the glycogen content in liver compared with the control group (P< 0. 01). It is suggested that the novel glycoprotein from Cyanea nozakii possess the activity to promote the anti-fatigue activity of mice.%本文对霞水母糖蛋白的抗疲劳作用进行了研究.试验中分别以50、100、200 mg/kg剂量的霞水母糖蛋白经口给予小鼠连续灌胃30 d,然后分别进行小鼠负重游泳试验、血清尿素氮、肝糖原及血乳酸测定.结果显示,霞水母糖蛋白各剂量组小鼠的游泳时间明显长于对照组(P<0.01);各剂量组小鼠运动后血清尿素氮含量低于对照组(P<0.05或P<0.01);中、高剂量组小鼠肝糖原含量均明显高于对照组(P<0.01);各剂量组小鼠运动后的血乳酸含量均小于对照组(P<0.01).从而表明,霞水母糖蛋白具有抗疲劳作用.