N-酰化低聚壳聚糖衍生物还原能力的研究

摘要

对低聚壳聚糖进行N-酰化改性,制得取代度相同的N-马来酰低聚壳聚糖(NMCOS),N-琥珀酰低聚壳聚糖(NSCOS),N-邻苯二甲酰低聚壳聚糖(NPCOS),其中NMCOS1、NSCOS1、NPCOS1的取代度均为0.25;NMCOS2、NSCOS2、NPCOS2的取代度均为0.49.考察了6种N-酰化低聚壳聚糖衍生物的还原能力.结果表明:当取代度相同时,N-邻苯二甲酰低聚壳聚糖的还原能力最强,其次是N-马来酰低聚壳聚糖,N-琥珀酰低聚壳聚糖的还原能力最差.这可能是由取代基的性质不同所致.%N-maleoyl chitosan oligosaccharide (NMCOS), N-succinyl chitosan oligosaccharide (NSCOS) and N-phthaloyl chitosan oligosaccharide (NPCOS) with the same substituting degree were prepared by N-acylation of chitosan oligosaccharide.The substituting degrees of NMCOS1, NSCOS1 and NPCOS1 were 0.25.The substituting degrees of NMCOS2, NSCOS2, and NPCOS2 were 0.49.Their power reducing were evaluated and the results showed the order of the power reducing of the N-acyl chitosan oligosaccharide with the same substituting degrees is NPCOS ＞ NMCOS ＞ NSCOS.That may be related to the properties of the substituting groups.