漏斗大孔菌的化学成分研究

摘要

采用硅胶、RP-18、Sephadex LH-20等多种材料进行分离纯化,通过理化方法和波谱分析进行结构鉴定,从漏斗大孔菌发酵液的乙酸乙酯萃取部分中分离并鉴定了8个化合物,分别为:5-(hydroxymethyl)-1,1,4a-trim-ethyl-6-methylenedecahydronaphthalen-2-ol (1)、albicanol (2)、D-阿洛醇(3)、对羟基苯甲醛(4)、胡萝卜苷(5)、trilinolein(6)、3β,5α,9α-三羟基-麦角甾-7,22-二烯-6-酮(7)和麦角甾-7,22-二烯-3-酮(8).所有化合物均为首次从该真菌中分离得到.%Eight compounds were separated and purified from the ethyl acetate extracts in the fermentation liquid of Favolus arcularius by silica gel,Rp-18,and Sephadex LH-20 column chromatography,respectively. Their structures were identified as 5-(hydroxymethyl)-1, 1,4a-trimethyl-6-methylenedecahydronaphthalen-2-ol (1) ,albicanol (2). D-allitol (3) ,4-hydroxybenzaldehyde (4) , daucosterol (5) , trilinolein (6) ,and 3β,5a,9a-trihydroxyergosta-7,22-dien-6-one (7) ,and ergosta-7 ,22-dien-3-one (8) on the basis of physicochemical properties and spectroscopic analysis. All the compounds were isolated from the fungi for the first time.