Objective Through comparing the Clinical characteristics and high risk factors for Invasive Fungal Infection in neonatal intensive care unit, to improve prevention and treatment of invasive fungal infection. Method We analysed the clinical characteristics and laboratory inspection of 31 infants Who were detected with invasive fungal infection in our NICU between May,2007 to April, 2012, and selected the control group(50 cases), matched by similar admission time, gestational age, birth weight, hospital stay, and performed the comparative analysis of risk factors for invasive fungal infection. Results The major clinical manifestations of neonatal invasive fungal infection were feeding intolerance, apnea, temperature instability and reaction delay. Laboratory examination: Elevated c-reactive protein and thrombocytopenia are more sensitive indicators, whereas the proportion of abnormal white blood cell counts is only 32.3%. The analysis of risk factors for Invasive Fungal Infection showed: use broad spectrum antibiotics more than 7 days, mother has mycotic vaginitis, central venous catheterization more than 14 days, mechanical ventilation more than 48 hours, these four indicators had statistical difference between two groups. Conclusion Neonatal invasive fungal infection needs comprehensive prevention and treatment.% 目的通过对NICU中新生儿深部真菌感染的临床特点分析及相关的高危因素对比,进一步提高深部真菌感染的防治水平.方法对2007年5月-2012年4月间我院NICU确诊的31例深部真菌感染的患儿进行临床特点、实验室检查结果分析,并根据相似的入院时间、胎龄、出生体重、总住院日设立50例对照组,进行深部真菌感染高危因素的对比分析.结果新生儿深部真菌感染的主要临床表现以喂养困难、呼吸暂停、体温不稳定和反应差等,实验室检查提示CRP升高、血小板减少为较敏感的指标,而白细胞异常的比例仅32.3%.深部真菌感染的高危因素分析显示：使用广谱抗生素>7d,母亲有霉菌性阴道炎,深静脉置管>14d,呼吸机治疗>48h4个指标在两组间有统计学差异.结论新生儿深部真菌感染需综合防治.
展开▼
