2型糖尿病真胰岛素和胰岛素原水平改变的初步探讨

摘要

Objective To study the clinical significance of true insulin (TI)and proinsulin (PI)determination in evaluat-ing the islet β-cell function. Methods Blood glucose,immune reactive insulin (IRI),TI and PI were detected in fasting glu-cose in 30 recent diagnosed patients with type 2 diabetes mellitus(DM), and 44 cases of normal glucose tolerance(NGT). Re-sults The lever of PI and PI/IRT in type 2 DM group were higher than that in NGT group, including the changes of PI/IRT were significant(P<0.01). The lever of TI/IRT in type 2 DM group were lower than that in NGT group,also the changes of TI/IRT were significant (P<0.01). Conclusion The abnormity of TI and PI lever may be one of the important markers of islet β-cell dys-function in T2DM. The determination of TI may have a great accurancy than IRI in comparing islet β-cell function between NGT and T2DM.%　　目的探讨真胰岛素和胰岛素原在评估胰岛β细胞功能中的临床意义.方法正常对照组(NGT)44例和初发2型糖尿病组(DM)30例分别检测空腹血糖、免疫反应性胰岛素(IRI)、胰岛素原(PI)、真胰岛素(TI).结果糖尿病组的PI水平、PI/IRI高于正常对照组，同时其TI/IRI低于正常对照组，且PI/IRI及TI/IRI差异具有显著性(P<0.01).结论 T2DM患者存在PI、TI水平的异常是糖尿病患者胰岛β细胞功能缺陷的重要表现之一，因此T2DM患者测定PI、TI水平更能反映胰岛β细胞功能从而减少PI对检测结果干扰.