地五养肝方联合恩替卡韦治疗乙型肝炎病毒相关性肾炎的疗效及对白介素-2、γ-干扰素的影响

摘要

Objective It is to observe the effect of entecavir combined with Diwu Yanggan anagraph ( DWYGA) in treat-ment of hepatitis B virus associated nephritis ( HBV-GN) and its influence on IL-2 and IFN-γ.Methods 21 patients with HBV-GN were received entecavir combined with DWYGA for at least 36 weeks.The changes of clinical symptom and signs , liver and kidney function , 24hUAlb, HBV DNA, IL-2 and IFN-γwere observed.Results Compared with pre -therapy, the clinical symptom and signs, liver and kidney function of patients with HBV -GN were markedly improved (P<0.01). The total effective rate was 86%, HBVDNA negative rate was 81%.The levels of IL-2 and IFN-γwere markedly height-ened than pre-therapy ( P<0.01 ) .Conclusion The combined therapy with entecavir and DWYGA is effective for HBV -GN.The mechanism may be relevant to efficient anti -virus, regulate the body’s immune function, and reduce the damage on kidney and liver .%目的：观察地五养肝方联合恩替卡韦治疗乙型肝炎病毒相关性肾炎（ HBV-GN）的疗效及其对白介素-2（ IL-2）、γ-干扰素（ IFN-γ）的影响。方法21例HBV-GN患者予以地五养肝方联合恩替卡韦治疗36周，观察患者临床症状、体征，检测患者肝肾功能、24 h尿蛋白定量、HBV DNA水平及血清IL-2、IFN-γ水平等。结果治疗36周后，HBV-GN患者临床症状、体征、肝肾功能较前明显改善（P均＜0．01）；总有效率86％，HBV DNA转阴率81％；血清IL-2、IFN-γ水平较治疗前明显升高（ P均＜0．01）。结论恩替卡韦联合地五养肝方治疗HBV-GN疗效显著，其作用机制可能与高效抗病毒、调节机体的免疫功能及减少肝肾的免疫损伤等有关。