猪瘟病毒E2蛋白研究进展

摘要

Classical swine fever(CSF)is a highly contagious, acute, hyperthermic, multi-systemic hemorrhagic viral disease of pigs, which caused by classical swine fe-ver virus(CSFV), a member of the genus Pestivirus of the Flaviviridae. CSF is preva-lent in all continents except North America and Oceania,it is distributed worldwide, and it has relapsed in some European countries(Netherlands, Belgium, Britain, Germa-ny, Italy, Spain, etc.)which had eliminated CSF. Although we have used HCLV vaccine for inoculation for a long time,but CSF still exists in our country and happens from frequency of pandemic into erratic regional dissemination. Latent and persistent in-fection has increased. Therefore, we need clear swine fever virus genome structure and the most research value immunological antigen protein structures to provide a theoretical basis for the development of new and effective vaccines and diagnostic reagents. In this paper,we have reviewed the research progress in genomic structure of CSFV,structure, function, epitopes,expression and applications of E2 protein.%猪瘟（Classical Swine Fever，CSF）是由猪瘟病毒（Classical Swine Fever Virus，CSFV）引起的一种急性、接触性传染病。目前该病流行于除北美洲和大洋洲以外的其他大洲和地区，呈世界性分布，在一些原已宣布消灭猪瘟的欧洲国家（荷兰、比利时、英国、德国、意大利、西班牙等）又相继复发。虽然我国长期坚持全面接种猪瘟兔化弱毒疫苗，但目前猪瘟在我国依然存在，流行特点从以往的频发大面积流行转变为无规律区域性的散发，隐性持续性感染病例增多，因此应明确猪瘟病毒的基因组结构和最具免疫防制研究价值的抗原蛋白结构，为研制新型有效的疫苗和诊断试剂提供理论依据。本文就猪瘟病毒的基因组结构、猪瘟病毒E2蛋白的结构、功能、所包含的抗原表位以及E2蛋白的表达应用等方面的研究进展作以综述。