目的：观察脱氧核苷酸注射液联合负压引流技术（VSD）治疗开放性骨折的有效性与安全性。方法入选我院48例开放性骨折患者，所有患者相应的外固定、VSD、皮瓣移植、抗感染、消肿及抗凝治疗。治疗组24例在基础治疗上给予脱氧核苷酸注射液冲洗联合静脉滴注。对照组24例在基础治疗上给予生理盐水治疗。结果治疗组创面完全愈合时间，骨折愈合时间（d），骨折延迟愈合发生率，皮片成活面积（%）分别为25．7±7．8，71．2±21．2，0%，97．2±2．4%；对照组分别为31．4±7．4，77．9±23．2，16．7%，89．6±2．8%；两组比较具有统计学差异（P<0．05）。另外rh-aFGF治疗后，治疗组水肿评分、疼痛评分、中重度感染发生率分别为2．0±0．2，1．6±0．2，8．3%；对照组分别为3．8±0．6，3．7±0．2，50．0%；两组比较具有统计学差异（P<0．05）。治疗过程中，两组均未发生明显的不良反应。结论脱氧核苷酸注射液与VSD联合治疗，可加速创面愈合，减轻手术后并发症，减少感染发生。%Objective Observation ODN injection combined with vacuum assisted(VSD) open fracture treatment effectiveness and safety.Methods 48 cases of open fractures enrolled patients in our hospital, the corresponding external fixation,VSD and flap transplantation in the treatment of all patients.Results Treated the wounds healing time, fracture healing time (d), the incidence of de-layed union fractures, skin graft survival area (%) were 25.7 ±7.8,71.2 ±21.2,0%, 97.2 ±2.4%; the control group were 31.4 ±7.4,77.9 ±23.2,16.7%,89.6 ±2.8%; compare the two groups was significant difference (P<0.05). Also after rh-aFGF treatment group edema score, pain score, the incidence of severe infection was 2.0 ± 0.2,1.6 ± 0.2,8.3%, respectively; the control group was 3.8 ± 0.6,3.7± 0.2,50.0%; two Comparison with a statistically significant difference (P<0.05). The course of treat-ment, the two groups were not significant adverse reactions.Conclusions ODN injection and VSD combination therapy, can accelerate wound healing and reduce post-surgical complications, reduce infection.
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