辛伐他汀对维持性腹膜透析患者微炎症状态的影响

摘要

Objective To explore the influence of Simvastatin on microninflammatory state in peri-toneal dialysis patients.Methods In 41 peritoneal dialysis patients and 20 healthy controls the level of high￣sensitivity C￣reactive protein (Hs￣CRP), Interlukin￣6 (IL￣6), Tumor necrosis factor-a (TNF￣a) and serum lipid level were determined,then the patients were randomly divded into 2 groups to receive simvastatin 20mg daily or nonlipid-lowering therapy.All above parameters were assayed again after 24 weeks.Results (1)Compared with healthy controls,the serum TG、Hs￣CRP、IL￣6、TNF￣a were elevated significantly in peritoneal dialysis patients (P<0.01). (2)After 24 weeks'treatment,the level of TG,TC、Hs￣CRP、IL￣6 and TNF￣a in simvastatin group were lower than be-fore,and the level of Hs￣CRP、IL￣6和TNF￣a was much lower in simvastatin group than non￣sim-vastatin group (P<0.05).Conclusion Simvastatin can relieve the microninflammatory state in peri-toneal dialysis patients.%目的：探讨辛伐他汀对维持性腹膜透析患者微炎症状态的影响。方法选择肾内科维持性腹膜透析患者41例,测定甘油三酯(TG)、总胆固醇(TC)、超敏C反应蛋白(Hs￣CRP)、白细胞介素￣6(IL￣6)和肿瘤坏死因子￣a（TNF￣a）的水平,然后随机分为辛伐他汀治疗组（22例）和非辛伐他汀治疗组（19例）。治疗24w后检查TG、TC、Hs￣CRP、IL￣6和TNF￣a。并设20例健康者作对照比较。结果（1）维持性腹膜透析患者TG、Hs￣CRP、IL￣6和TNF￣a显著高于健康者(P＜0.01)；（2）治疗后24w，辛伐他汀治疗组TG、TC、Hs￣CRP、IL￣6和TNF￣a的水平均有所下降，辛伐他汀治疗组Hs￣CRP、IL￣6和TNF￣a下降的水平与治疗前及非辛伐他汀治疗组相比，差异具有显著性（P＜0.05）。结论辛伐他汀能明显改善维持性腹膜透析患者的微炎症状态。