Effect of Shenmai injection combined with irbesartan on the microinflammatory state and nutritional status of patients with peritoneal dialysis

摘要

Objective: To study the effect of Shenmai injection combined with irbesartan on themicroinflammatory state and nutritional status of patients with peritoneal dialysis. Methods:A total of 108 patients with end-stage renal disease who received peritoneal dialysis inGuangyuan First People’s Hospital between May 2014 and November 2016 were selected andrandomly divided into two groups, the combined group received Shenmai injection combinedwith irbesartan therapy, and the ARB group received irbesartan therapy. The renal functionindicators, inflammatory response indicators and nutritional status indicators of the two groupswere detected before treatment as well as 3 months and 6 months after treatment. Results: Scr,BUN and RRF of both groups 3 months and 6 months after treatment were not significantlydifferent from those before treatment; serum SAA, CRP, PAPP-A, CHE, TNF-α, IL-6and IL-8 contents of both groups 3 months and 6 months after treatment were significantlylower than those before treatment, and serum SAA, CRP, PAPP-A, CHE, TNF-α, IL-6 andIL-8 contents of combined group 3 months and 6 months after treatment were significantlylower than those of ARB group; serum Alb, PA and Tf contents as well as mid-arm musclecircumference and mid-arm circumference of combined group 3 months and 6 months aftertreatment were not significantly different from those before treatment while serum Alb, PA andTf contents as well as mid-arm muscle circumference and mid-arm circumference of controlgroup 3 months and 6 months after treatment were significantly lower than those beforetreatment. Conclusion: Shenmai injection combined with irbesartan for peritoneal dialysis canreduce the microinflammatory state and improve the nutritional status.