细菌的噬菌体感染耐受机制研究进展

摘要

噬菌体是能感染细菌的病毒，在自然界中分布十分广泛。随着发酵工业中的噬菌体污染以及多药耐药菌株的出现，噬菌体越来越受到关注。噬菌体感染细菌包括吸附、注入、复制、组装、释放等环节；细菌在与噬菌体的共进化过程中，针对这些环节产生了不同的抗感染机制。该文围绕抗吸附、超感染排斥、限制修饰系统、CRISPR系统、流产感染、组装感染等细菌的噬菌体感染耐受机制研究进行了简要综述。%Bacteriophages are abundantly distributed viruses , which are able to infect bacteria .Bacteriophages are becoming a focus of attention for microbiologists , as they can cause pollution to the fermentation industry and might serve as alternative therapies for antibiotic-resistant pathogenic bacteria .Effective bacteriophage infection normally involves adsorp-tion, injection, replication, assembly and release , against which bacteria have developed various resistance strategies .The research progress in the bacteriophage resistance mechanisms is briefly reviewed in this paper .