CONSTRUCTION OF MODIFIED FILAMENTOUS BACTERIOPHAGE FOR TREATMENT OR PROPHYLAXIS OF BACTERIAL INFECTION, MODIFIED BACTERIOPHAGE M14, PHARMACEUTICAL COMPOSITION AND METHOD FOR TREATMENT OF BACTERIAL INFECTION, MONOCLONAL ANTIBODY, HYBRIDOMA (VARIANT)

摘要

FIELD: medicine, virology, pharmacy. SUBSTANCE: invention relates to bacteriophages used in treatment or prophylaxis of bacterial infections, especially bacterial infections of mucosa. For this purpose the bacteriophage construction carrying on its surface recombinant protein containing bacteriophage surface protein and sequences of variable region of ScRv- polypeptide is prepared. The strain of modified bacteriophage m13 and construction are useful for treatment or prophylaxis of bacterial infection as component of pharmaceutical composition. The strain, construction and pharmaceutical composition are used in method for treatment of bacterial infection. Also, monoclonal antibodies are prepared from hybridomas 5F8, 2H6 and 5D8 that provide binding the modified bacteriophage M13 with Helicobacter pylori. EFFECT: improved preparing method, valuable medicinal properties of modified bacteriophage. 17 cl, 6 ex