A MODIFIED PNA COMPOUND HAVING ANTIBACTERIAL ACTIVITY, A COMPOSITION FOR THE PREVENTION OR TREATMENT OF BACTERIAL INFECTION, A COMPOSITION AND METHOD FOR THE DISINFECTION OF NONLIVING OBJECT

摘要

A novel compound is provided to show anti-bacterial activity. A composition comprising the same is provided to prevent or treat efficiently bacterial infection or disinfect a non-living object. A compound is represented by the formula(1) of peptide-L-PNA, where the peptide is an amino acid sequence, L is an linker or a bond, and PNA is a peptide nucleic acid and selected from the group consisting of -CGCCCAATAAT-NH2, -TCAGCGTCAGT-NH2, -CCAACATCTCA-NH2 and -TCTCAGTCCCA-NH2, wherein A is N-(2-aminoethyl)-N-(N6-(benzyloxycarbonyl)adenine-9-yl-acetyl)glycine, T is N-(2-aminoethyl)-N-(thymine-1-yl-acetyl)glycine, G is N-(2-aminoethyl)-N-(N2-(benzyloxycarbonyl)guanine-9-yl-acetyl)glycine and C is N-(2-aminoethyl)-N-(N4-(benzyloxycarbonyl)cytosine-1-yl-acetyl)glycine. A composition for preventing or treating bacterial infection comprises the compound and a pharmaceutically acceptable carrier. A method for disinfecting a non-living object comprises a step of contacting a composition for disinfecting the non-living object comprising the compound and a carrier with the non-living object.