Methods for extracting or inducing, in a mammal, a parasite-directed immune response, to treat a mammal for parasitic infection therapeutically or prophylactically, for the treatment and / or prophylaxis of an unhealthy mammalian condition, use of a composition, composition, vaccine composition, pharmaceutical composition, antibody for inhibiting, stopping or delaying the onset or progression of an unhealthy mammalian condition, use of an antibody, methods for detecting an immunoreactive molecule directed at a microorganism in a biological sample and to detect, monitor or otherwise evaluate an immune response directed to a microorganism in an individual, modular kit, method for analyzing, designing and / or modifying an agent capable of interacting with an anti-gpi glycan immunointeractive molecule binding site. , and, agent use

摘要

"METHODS FOR EXTRACTING OR INDUCTING, IN A MAMMER, AN IMMUNE RESPONSE TO A PARASITE, TO TREAT A THERAPEUTIC OR PROPHYLATIC MAMMER, FOR THE TREATMENT AND / OR PROPHYALISIS OF A CONDITION A COMPOSITION, COMPOSITION, VACCINE COMPOSITION, ANTIBODY PHARMACEUTICAL COMPOSITION, METHOD FOR INHIBITING, STOPPING OR DELAYING THE CONDITION OF A MAMMOTHER'S DISEASE, ANTIBODY ANTIBODY IMMEDIATE CONDITION A MICRO-ORGANISM, AND TO DETECT, MONITOR OR OTHERWISE ASSESS AN IMMUNE RESPONSE DIRECTED TO AN INDIVIDUAL, MODULAR KIT, METHOD FOR ANALYZING, DESIGNING AND / OR MODIFYING AN ABITITIA IMAGINA SIDE AGENT WITH AN IMPACT -GPI GLYCAN, AND, USE OF AGENT ". The present invention generally relates to a method for extracting or otherwise inducing an immune response to a microorganism and compositions for use therein. More particularly, the present invention relates to a method for inducing an immune response to a parasite using an immunogenic composition comprising a giclosylphosphatidylinositol inositolglican domain (referred to herein as 'GPI'), or its derivative or equivalent. The present invention is usable, inter alia, as a prophylactic and / or therapeutic treatment for mammalian microorganism infections such as parasitic infections and particularly Plasmodium species infections. In another aspect, the invention provides a method for diagnosing, monitoring, sorting or otherwise evaluating qualitatively or quantitatively an immune response to a microorganism and particularly a parasite. More particularly, this aspect of the present invention is directed to the evaluation of said immune response using a GPI inositolglican domain or its derivative or equivalent. The development of this aspect of the present invention facilitates, inter alia, the qualitative and / or quantitative analysis of anti-GPI antibodies in a biological sample, the identification and / or isolation of unique specificities of antibodies (such as those that bind a parasite-derived toxin). or the parasite itself), epitope-specific screening or rational design of immunogenic molecules, and thus generation of functionally effective immunointeractive molecules.