Objective To explore the effect of vitamin D in combination with metformin ovulation in treatment of patients with polycystic ovary syndrome ( PCOS) and the receptivity of endometrium .Methods 108 cases of patients with polycystic ovary syn-drome treated in department of gynaecology , were randomly divided into two groups by double blinding .52 cases were treated with rou-tine western medicine , with oral metformin 500 mg/d, taking three times , four weeks for a period of treatment .Experimental group with 56 cases, on the basis of conventional western medicine treatment with vitamin D , oral 1200 IU/d, four weeks for a period of treatment.After a period of treatment , two groups of patients with ovulation , carry on comparative analysis to the receptivity of endome-trium.Results ①After treatment, patients in the experimental group with ovulation cycle number , ovulation occurring and total ovu-lation rate (25, 18, 32.14%) was significantly higher than that of control group (13, 6, 11.53%), the difference was statistically significant (P<0.05).②Two groups of patients with endometrial thickness is reduced after treatment , and the experimental group (6.29 ±2.71, 82.19%) was significantly better than the control group (7.69 ±2.53, 89.32%), the difference was statistically sig-nificant (P<0.05).Two groups of patients with endometrial multilayer rate were decreased .The experimental group was significantly lower than the control group, the difference was statistically significant (P<0.05).③After treatment, two groups of patients with en-dometrial blood flow rate were decreased , and the experimental group ( 60.23%) was significantly lower than the control group (88.91%), the difference was statistically significant (P<0.05).④Two groups of patients after total effective salle grading compari-son:after treatment, the experimental group (13.27) in patients with salle score was significantly lower than the control group (17.52), the difference was statistically significant (P<0.05).Conclusion Vitamin D in combination with metformin cocoa effec-tively increase ovulation rate , reduce the patients with endometrial thickening , reduce multilayer rate , improve and vascular blood flow, the uterus is an effective drug for treatment of patients with polycystic ovary syndrome , and is worth clinical popularizing widely .%目的：探究维生素D联合二甲双胍对多囊卵巢综合征患者排卵及子宫内膜容受性的影响。方法选取某院妇科收治的多囊卵巢综合征108例，采用双盲随机分为两组。对照组52例，患者口服二甲双胍500 mg，3次／d，4周为一个疗程；观察组56例，在口服二甲双胍的基础上用维生素D，口服1200 IU／d，4周为一个疗程。一个疗程结束后，对两组患者排卵、子宫内膜容受性等情况进行比较分析。结果①治疗后，观察组排卵周期数、排卵例数及总排卵率（25、18、32．14％）显著高于对照组（13、6、11．53％），差异有统计学意义（P＜0．05）；②治疗后，两组患者子宫内膜厚度均有所减小，且观察组（6．29±2．71、82．19％）显著优于对照组（7．69±2．53、89．32％），差异有统计学意义（P＜0．05），两组患者子宫内膜多层率均有所下降，且观察组显著低于对照组，差异有统计学意义（ P＜0．05）；③治疗后，两组患者子宫内膜血流量有所下降，且观察组（60．23％）显著低于对照组（88．91％），差异有统计学意义（P＜0．05）；④治疗后，观察组患者Salle评分13．27分显著低于对照组17．52分，差异有统计学意义（P＜0．05）。结论维生素D联合二甲双胍可有效提高患者排卵率、减少子宫内膜增厚、减轻子宫多层率、改善子宫血管血流量，是治疗多囊卵巢综合征患者的有效药物，值得临床推广。
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