Comparison of the Effects of Clomiphene Citrate Alone Versus Combined Metformin and Clomiphene Citrate in Increasing Ovulation and Fertility in Patients with Polycystic Ovarian Syndrome with Anovulatory Infertility

摘要

OBJECTIVES: To evaluate the effects of clomiphene citrate alone versus combined metformin and clomiphene citrate in patients ofpolycystic ovarian syndrome with anovulatory infertility in increasing ovulation and pregnancy rate.STUDY DESIGN: A Randomized controlled study.PLACE AND DURATION: The study was done at the infertility clinic of Gynaecology and Obstetrics dept of KRL hospital Islamabad forone year from 16th November, 2009 till 15th November, 2010.METHODOLOGY: 74 diagnosed patients of PCOS with anovulatory infertility were included in the study. Simple random sampling wasdone and 37 patients of group A were given clomiphene citrate from 50-150 mg on 2nd – 6th day of menstrual cycle, for 6 cycles.The patients of group B were given Metformin 1.5 gms daily for 6 months alongwith clomiphene citrate 50-150 mg on 2nd -6th day ofmenstrual period, maximum 6 cycles. Ovulation was monitored by transvaginal sonography and serum progesterone levelmeasurement which was done on 21st day of the cycle. Pregnancy was confirmed by serum B-hCG.RESULTS:CONCLUSION: The results proved that metformin along with clomiphene citrate significantly improves ovulation and pregnancy ratein patients of PCOS with anovulatory infertility and the combination of both drugs produced far better results than clomiphene citratealone.