猪瘟病毒与宿主天然免疫系统的相互作用

摘要

猪瘟(Classical swine fever,CSF)是由猪瘟病毒(Classical swine fever virus,CSFV)感染引起的一种高度接触性传染病,临床上以出血综合征与免疫抑制为主要特征.它在多个国家流行,给中国乃至世界养猪业造成巨大的经济损失.研究表明,猪瘟病毒感染能够诱导宿主的天然免疫应答,也能通过影响天然免疫效应分子的表达来抑制宿主的天然免疫功能.本文将对猪瘟病毒感染与天然免疫应答及其免疫抑制的现象与机理进行综述.%Classical swine fever (CSF) caused by classical swine fever virus (CSFV),is a highly contagious disease of swine that is characterized by hemorrhage syndrome and immunosuppression.It is one of the most important swine diseases worldwide and leads to significant economic loss in the pig industry in China and other regions of the world.Studies have shown that infection with CSFV can induce host innate immune response,but this virus can suppress the host innate immunity through influencing the expression of effector molecules of the innate immune system.In this review,we highlight the current understanding of host innate immune response and immune suppression during CSFV infection.In addition,we review the mechanisms by which CSFV infection induces innate immunity and its suppression.