阴道上皮内瘤变与TCT、高危型HPV感染、宫颈病变的关系探讨

摘要

探讨阴道上皮内瘤变(VaIN)与TCT、高危型 HPV感染、宫颈病变的关系.收集2015年1月~2017年1月因细胞学筛查异常行阴道镜和组织学检查,诊断为VaIN的患者128例.计数资料组间比较应用卡方检验和Kruskal Wallis检验.(1)VaIN患者中≥40岁者高度病变发现率与<40岁者高度病变发现率差异有显著性;(2)VaIN患者中,单一感染与多重感染差异有显著性;(3)VaIN的高度病变在TCT为LSIL及以下者中的发现率与在TCT为ASC-H、HSIL及癌者(以下记做≥ASC-H)的发现率差异有显著性;(4)宫颈病理为低度病变及以下者VaIN的高度病变发生率与病理为高度病变及以上者,VaIN的高度病变发生率差异有显著性.VaIN与高危型 HPV感染及宫颈病变的关系密切,在临床中应重视对阴道上皮的检查.%To discuss the relationship of vaginal intraepithelial neoplasia(VaIN),thinprep cytologic test(TCT),high-risk human papilloma virus(HR-HPV)and cervical intraepithelial neoplasia(CIN).A total of 128 cases of VaIN patients were retrospectively analyzed with abnormal examination results from Jan,2015 to Jan,2017.They were all proceeded colposcopy and histological examination.The χ2-test and Kruskal Wallis test were used.(1)The VaIN of HSIL in 40 or more than 40 years old patients was significantly higher than in less than 40 years old patients;(2)Among 128 patients, there was a significant difference between the single infection rate and the multiple one;(3)The HSIL of VaIN in high class or cancer of TCT was significantly higher than in low class;(4)The HSIL of VaIN in high class patients of pathological diagnosis was significantly higher than in low class patients.VaIN,HR-HPV,and CIN were closely and we should more attention to the examination of vaginal epithelium in clinical work.