目的：探讨超声对分别首次服用奥氮平和阿立哌唑的精神分裂症患者胃排空功能的影响。方法40例精神分裂症首次发病患者随机服用奥氮平和阿立哌唑各20例，用实时二维B超胃窦单切面法测量治疗前及治疗4周后空腹胃窦面积（S空腹）、胃排空时间（T）、胃窦收缩频率（F）、胃窦收缩幅度（△S），观察药物对各项胃动力指标的影响。结果奥氮平组治疗前胃排空时间为57.04±9.86min，治疗后为52.35±9.86min，经药物治疗后，奥氮平组较治疗前胃排空时间变短。奥氮平组治疗前胃窦收缩幅度、收缩频率分别为2.09±0.59cm2和2.72±0.35次/分，治疗后分别为2.60±0.73cm2和2.98±0.70次/分，较治疗前胃窦收缩幅度增大、收缩频率加快。阿立哌唑组治疗前胃排空时间为62.69±12.09min，治疗后为64.81±12.16min，胃窦收缩幅度、收缩频率分别为2.68±0.83cm2和3±0.90次/分，治疗后分别为2.62±0.73cm2和2.75±0.86次/分，阿立哌唑组治疗前后各项指标变化无明显差异。结论奥氮平组精神分裂症患者胃排空加快，胃窦收缩幅度增大、收缩频率加快，胃动力改变时患者体重增加的发病机制之一，阿立哌唑组患者胃排空功能无明显变化。%Objective To explore the influence of ultrasonography patients with first-episode Schizophrenia on gastric emptying.Methods 40 patients with first-episode schizophrenia were randomly divided into olanzipine group(20 cases)and aripiprazole group(20 cases)for 4 weeks treatment.Gastric emptying time、antral contraction frequency and antral aera were measured using B-ultrasonography before treatment,Gastric emptying Function was reviewed 4 weeks after treatment.The efficacies of both drugs were assessed. Results In olanzipine group,Gastric emptying time Were 57.04 ± 9.86 min before treatment,after treatment were52.35 ± 9.86 min,the time were quicker than before treatment.antral contraction amplitude and contraction frequency were2.09 ± 0.59cm2 and 2.72 ± 0.35 times/min in olanzipine group,after treatment were 2.60 ± 0.73cm2 和 2.98 ± 0.70 times/min in olanzipine group,increased significantly after the treatment (P<0.05).In aripiprazole group,total emptying time were 62.69 ± 12.09 min before treatment,after treatment were 64.81 ± 12.16min,antral contraction amplitude and contraction frequency were 2.68± 0.83cm2和3± 0.90 times/min,after treatment were 2.62± 0.73cm2和2.75± 0.86 times/min,Each indexes of aripiprazole group were not changed after the teatment (P>0.05).Conclusion Gastric empyting rate is quiker than before treatment of olanzapine,the change of gastric emptying rate maybe is one of the fators of obesity in weight weight gain. Each indexes of aripiprazole group were not changed.
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