骨源性碱性磷酸酶测定在家兔骨折修复过程中的意义

摘要

Objective To explore the applicative valuation of bone alkaline phosphatase in the fracture healing. Methods 50 healthy adult New Zealand rabbits were made artificial fracture. At Week4 and Week8 following operation X-ray flim was tanken 50 New Zealand rabbits were divided to group 0 to 4 by the x ray manifstantion They were examined by ALP and BALP in each group, the average was taken and then the results were anuluzed and compared. Results In the fracture healing, The level of ALP and BALP were significant different. BALP test was sensitivier than ALP. conclusion The BALP is a dependable sensitive sign that can be used to determine earlier period of he fracture healing. The level of BAP are important in early prediction of pathogenetic condition and observation of therapeutic efficacy%　　目的探讨骨源性碱性磷酸酶(BALP)测定在骨折修复过程中的应用。方法健康大耳新西兰兔50只,制作骨折模型。在4周末及8周末时,分别拍摄骨折X线片,根据X线评分分组；分别在各组每只新西兰兔测定碱性磷酸酶(ALP)及BALP；取每组平均值,检验结果进行比较及分析。结果在骨折修复过程中ALP及BALP水平有显著的变化,BALP更明显。结论 BALP在骨折修复早期可以作为一个敏感性强的参考指标,其水平变化在预测病情进展、观察临床治疗效果方面具有重要的意义。