细胞凋亡与血管再生促进纤维化发展的机制研究

摘要

Fibrosis is usually seen in the liver, lung, heart, kidney and skin. Apoptosis has been identiifed as a potential initiator and propagator of fibrosis. The occurrence of apoptosis has an important effect on fibroblast phenotype and collagen metabolism. Simultaneously, fibrosis in these models is generally preceded by robust angiogenesis and vascular regression, suggesting that the vascular apoptotic burden may be important to ifbrotic outcomes. Angiogenesis inhibitors in the experimental research has shown good curative effect against liver ifbrosis. This review considers the emerging evidence that angiogenesis or vascular regression contributes to ifbrosis and identiifes initial vascular outgrowth or vascular apoptotic cell presence as possible regulators of ifbrosis.%纤维化经常发生在肝脏、肺、心脏、肾脏和皮肤等重要脏器。细胞凋亡已经被认定为纤维化潜在的启动和促进者。凋亡细胞的出现对成纤维细胞表型和胶原蛋白代谢有重要影响。同时，在纤维化的模型中发现血管生成和退化普遍出现在纤维化之前，暗示着血管凋亡对于纤维化是重要的。而且血管生成抑制剂在实验研究中已显示出较好的抗肝纤维化疗效。新近的证据表明血管生成或退化有助于纤维化，而最初的血管衍生物或凋亡细胞的出现可能是纤维化的调控者。