缺氧诱导因子1α与Gax基因对自体静脉移植术后内膜过度增生的调控机制

摘要

Intimal hyperplasia could reduce postoperative effects of venous autografts, HIF-1α and Gax gene might inhibit intimal hyperplasia after venous autografts,which is to become a new prevention and treatment of postoperation restenosis in vein graft.HIF-1α adjusts the expression of vascular endothelial cells growth factor,which plays an important role in recovery of structure and function of vascular endothelial cells.Gax gene can affect cell cycle and apoptosis to regulate the proliferation of vascular smooth muscle cells.%自体静脉移植术后内膜过度增生是影响术后效果的重要原因,缺氧诱导因子1α(HIF-1α)与Gax基因可以抑制自体静脉移植术后内膜过度增生,可作为治疗移植静脉再狭窄的一个新手段,HIF-1α通过调控血管内皮生长因子的表达,对恢复血管内皮细胞的结构和功能起着重要的调节作用,而Gax基因通过影响细胞周期和诱导细胞凋亡两条途径来调节血管平滑肌细胞的增殖.