EB病毒感染与儿童急性免疫性血小板减少性紫癜关系的初步探讨

摘要

目的 探讨Epstein-Barr病毒(EBV)感染与儿童急性免疫性血小板减少性紫癜(ITP)的关系.方法 分别用实时荧光定量聚合酶链反应(FQ-PCR)方法和血清酶联免疫吸附试验(ELISA)方法检测115例急性ITP患儿和50例健康儿童的EBV DNA和EBV IgM抗体.结果 急性ITP患儿EBV DNA、EBV IgM阳性率均明显高于健康对照儿童,差异均有统计学意义(P<0.01).结论 儿童感染EB病毒可能是儿童发生急性免疫性血小板减少性紫癜的重要因素之一.%Objective To explore the relationship between Epstein-Barr Virus ( EBV ) infection and acute immune thrombocytopenic purpura ( aITP ) in children.Methods EBV-DNA in peripheral blood and serum EBV-IgM in 115 cases with ITP and 50 healthy children were detected by fluorescence quantitative-polymerase chain reaction( FQ-PCR ) and enzyme linked immunosorbent assay( ELISA ).Results The positive rates of EBV DNA,EBV IgM in the aITP group were higher than in the control group.There were significant difference between the two groups( P ＜ 0.01 ).Conclusion EBV infection may be an important pathogenic factor of aITP in children.