WGAN Latent Space Embeddings for Blast Identification in Childhood Acute Myeloid Leukaemia

摘要

Acute Myeloid Leukaemia (AML) is a rare type of childhood acute leukaemia. During treatment, the assessment of the number of cancer cells is particularly important to determine treatment response and consequently adapt the treatment scheme if necessary. Minimal Residual Disease (MRD) is a diagnostic measure based on Flow CytoMetry (FCM) data that captures the amount of blasts in a blood sample and is a clinical tool for planning patients' individual therapy, which requires reliable blast identification. In this work we propose a novel semi-supervised learning approach, which is acquired whenever large amounts of unlabeled data and only a small amount of annotated data is available. The proposed semi-supervised learning approach is based on Wasserstein Generative Adversarial Network (WGAN) latent space embeddings learned in an unsupervised fashion and a simple Fully connected Neural Network (FNN) trained on labeled data leveraging the learned embedding. We apply our proposed learning approach for semi-supervised classification of blasts vs. non-blasts. We compare our approach with two baseline approaches, 1) semi-supervised learning based on Principal Component Analysis (PCA) embedding, and 2) a deep FNN that is trained only on the annotated data without leveraging an embedding. Results suggest that our proposed semi-supervised WGAN embedding outperforms semi-supervised learning based on PCA embeddings and if only small amounts of annotated data is available it even outperforms an FNN classifier.