ERK和JNK信号转导通路与疾病关系的研究进展

摘要

ERK信号通路激活能够促进细胞增殖,而JNK信号通路的激活与细胞凋亡关系密切,两者还参与多种疾病的病理生理变化过程.JNK信号转导通路与神经退行性病变或其他神经系统相关疾病有着密切联系.在肿瘤的发生以及浸润过程中ERK信号转导通路可能是其主要机制,ERK还参与疼痛的产生,ERK在细胞内的定位可能与神经变性有密切联系.%At present,most studies suggest that activation of ERK signaling pathway can promote cell proliferation and JNK signaling pathway are closely related with apoptosis. They are also involved in the pathophysiology change process of many diseases. JNK signal transduction pathway is closely related with neurodegenerative disease or other neurological diseases. ERK signal transduction pathway may be the main mechanism of tumorgenesis and invasiveness, which is also involved in the generation of pains. ERK intracellular localization may be closely related with neuro denaturation.