微小核糖核酸在参与缺血/再灌注过程中的研究进展

摘要

MicroRNA is a small non-coding regulation RNA in eukaryotes found in recent years. Its mechanism is mainly regulation of gene expression after transcription. A number of recent studies found that different miRNAs have different expression levels in ischemia-reperfusion of various tissues. Inflammatory reaction is one of the important factors of mediating ischemia-reperfusion injury, which indicates miRNA plays an important role in ischemia-reperfusion process. Further research of miRNA will have important clinical significance in the early diagnosis and treatment of ischemia-reperfusion injury.%微小核糖核酸(miRNA)是一种近年来发现的存在于真核生物中的非编码调控RNA,其作用机制主要是在转录后水平上调控基因的表达.不同 miRNA在炎性反应以及组织缺血/再灌注(I/R)过程中的表达水平有不同程度的变化,炎性反应是介导I/R损伤的重要因素之一,这一现象初步揭示了miRNA在I/R过程中扮演着重要的角色.深入研究将miRNA早期诊断和治疗I/R损伤有重要的临床意义.