饮食摄入维生素K对华法林抗凝治疗的影响

摘要

Influence of Diet Vitamin K Intake on Warfarin Anticoagulation Therapy PAN Deng,ZHAI Ming. (rnWarfarin as an oral vitamin K antagonist is widely used for anticoagulation. It is discovered in re-rent years that the diet vitamin K intake can greatly influence the warfarin response. High diet vitamin K intake causes insensibility of warfarin treatment and low diet vitamin K intake causes instability of warfarin treatment. Supplement of vitamin K or other diet intervention may increase the stability of warfarin treatment. The adjust-ment of vitamin K intake may become an alternative 01 warfarin to change piothiombin time-international normalrnized ratio.%维生素K拮抗剂华法林广泛应用于临床的抗凝治疗,近年来研究发现,饮食中维生素K的摄入对华法林治疗的反应有很大影响.高维生素K摄入与华法林初始治疗敏感性差相关,低维生素K摄入与华法林治疗的稳定性差相关.补充维生素K或其他饮食干预措施可能有助于提高华法林抗凝治疗的稳定性.调整饮食维生素K的摄入量替代调整华法林剂量有可能成为调整凝血酶原时间-国际标准化比值的另一种方法.