调节高密度脂蛋白治疗的研究进展

摘要

高密度脂蛋白的降低和功能失调是动脉粥样硬化的一个重要原因.一般认为,高密度脂蛋白水平与冠心病呈负相关,其机制包括胆固醇的逆向转运、抗氧化、抗血栓、调节内皮功能等.但是,由于高密度脂蛋白组成成分复杂,调节其功能比升高其总体水平更重要.目前调节高密度脂蛋白的治疗主要有改变生活方式、药物治疗以及新近的生物制剂,以期降低心血管疾病的发病率及病死率.%Reduced high-density lipoprotein and functional disorder is a vital cause of artherosclerosis. It's generally acknowledged that high-density lipoprotein is negatively correlated with cardiovascular heart disease, its mechanisms include reverse cholesterol transport, antioxidation, antithrombotic, and regulating endothelial function etc. . However, the composition of high-density lipoprotein is so complex that it's more important to regulate its function than to elevate its level. So far, the therapies include changing lifestyle, medication, and recent biological agent,hoping to lower the morbidity and mortality of cardiovascular disease.