Asprin has been widely used in the prevention and treatment of ischemic cerebrovascular disease, and aspirin resistance(AR)refers to thrombotic events or ineffective suppression though aspirin is applied , the causes of which are complex, including the drug interactions from improper application, insufficient dose ,cyclooxygenase-1 gene polymorphisms, infection , and metabolic disease etc. . A number of studies of evidence-based medicine confirmed: laboratory diagnosed AR patients have much higher risk of cerebrovascular events, lethal and sublethal cerebral vascular events than aspirin sensitive patients. Regular testing of platelet function, standard, combined and individualized medication for patients using aspirin can reduce the incidence of AR and thrombotic events, benefiting the patients.%阿司匹林被广泛应用于缺血性脑血管病的防治,阿司匹林抵抗(AR)是指应用阿司匹林治疗剂量仍有血栓事件发生或者血小板功能不能有效被抑制.导致这种现象的确切原因较复杂,包括不适当应用药物的相互作用,剂量不足,环氧化酶1基因的多态性,感染,代谢疾病等.大量循证医学研究证实,实验室诊断AR的患者,其脑血管事件风险,致死和非致死的脑血管事件的风险明显高于阿司匹林敏感者.对应用阿司匹林患者定期检测血小板功能,规范、联合、个体化用药可减低阿司匹林抵抗的发生率,减少血栓性事件,使患者受益.
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